RBM603 BM Syllabus
AKTU BIOMEDICAL ENGINEERING(BE) RBM603 BM Syllabus for all 5 units are provided below. Download link for BE 6th SEM RBM603 BIOMATERIALS Syllabus is listed down for students to make perfect utilization and score maximum marks with our study materials.
UP Technical University BIOMEDICAL ENGINEERING(BE) 6th SEM RBM603 BM– BIOMATERIALS Syllabus
RBM603 BIOMATERIALS
Unit-1
Introduction: Definition of biomaterials, requirements & classification of biomaterials, Comparison of properties of some common biomaterials. Effects of physiological fluid on the properties of biomaterials. Biological responses (extra and intra-vascular system). Surface properties of materials, physical properties of materials, mechanical properties.
Unit-2
Metallic implant materials: Stainless steel, Co-based alloys, Ti and Ti-based alloys. Importance of stress-corrosion cracking. Host tissue reaction with bio metal, corrosion behavior and the importance of passive films for tissue adhesion. Hard tissue replacement implant: Orthopedic implants, Dental implants. Soft tissue replacement implants: Percutaneous and skin implants, Vascular implants, Heart valve implants-Tailor made composite in medium.
Unit-3
Polymeric implant materials: Polyolefin’s, polyamides, acrylic polymers, fluorocarbon polymers, silicon rubbers, acetyls. (Classification according to thermo sets, thermoplastics and elastomers).Viscoelastic behavior: creep-recovery, stress-relaxation, strain rate sensitivity. Importance of molecular structure, hydrophilic and hydrophobic surface properties, migration of additives (processing aids), aging and environmental stress cracking. Physiochemical characteristics of biopolymers. Biodegradable polymers for medical purposes, Biopolymers in controlled release systems. Synthetic polymeric membranes and their biological applications.
Unit-4
Ceramic implant materials: Definition of bio ceramics. Common types of bio
ceramics: Aluminum oxides, Glass ceramics, Carbons. Bio resorbable and bioactive ceramics. Importance of wear resistance and low fracture toughness. Host tissue reactions: importance of interfacial tissue reaction (e.g. ceramic/bone tissue reaction).
Composite implant materials: Mechanics of improvement of properties by incorporating different elements. Composite theory of fiber reinforcement (short and long fibers, fibers pull out). Polymers filled with osteogenic fillers (e.g. hydroxyapatite). Host tissue reactions.
Unit-5
Biocompatibility & Toxicological screening of biomaterials: Definition of
biocompatibility, blood compatibility and tissue compatibility. Toxicity tests: acute and chronic toxicity studies (in situimplantation, tissue culture, haemolysis, thrombogenic potential test, systemic toxicity, intracutaneous irritation test), sensitization, carcinogenicity, mutagenicity and special tests.
TEXT BOOKS :
1. Biomaterials Science: An Introduction to Materials in Medicine, By Buddy D. Ratner, et. al. Academic Press, San Diego, 1996.
2. Sujata V. Bhat, Biomaterials, Narosa Publishing House, 2002.
3. J B Park, Biomaterials – Science and Engineering, Plenum Press, 1984.
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